Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and Vomiting
Open Access
- 26 July 2016
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Pharmacology
- Vol. 7, 221
- https://doi.org/10.3389/fphar.2016.00221
Abstract
Despite the advent of classic anti-emetics, chemotherapy-induced nausea is still problematic, with vomiting being somewhat better managed in the clinic. If post-treatment nausea and vomiting are not properly controlled, anticipatory nausea—a conditioned response to the contextual cues associated with illness-inducing chemotherapy— can develop. Once it develops, anticipatory nausea is refractive to current anti-emetics, highlighting the need for alternative treatment options. One of the first documented medicinal uses of Δ9-tetrahydrocannabinol (Δ9-THC) was for the treatment of chemotherapy-induced nausea and vomiting, and recent evidence is accumulating to suggest a role for the endocannabinoid system in modulating chemotherapy-induced nausea and vomiting. Here, we review studies assessing the therapeutic potential of cannabinoids and manipulations of the endocannabinoid system in human patients and pre-clinical animal models of nausea and vomiting.Keywords
Funding Information
- Natural Sciences and Engineering Research Council of Canada (92057)
- Canadian Institutes of Health Research (137122)
This publication has 101 references indexed in Scilit:
- Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2‐arachidonoyl glycerol attenuates nausea in ratsBritish Journal of Pharmacology, 2012
- Cannabidiol, a non‐psychotropic component of cannabis, attenuates vomiting and nausea‐like behaviour via indirect agonism of 5‐HT1A somatodendritic autoreceptors in the dorsal raphe nucleusBritish Journal of Pharmacology, 2011
- Motion Sickness, Stress and the Endocannabinoid SystemPLOS ONE, 2010
- Opportunities for the replacement of animals in the study of nausea and vomitingBritish Journal of Pharmacology, 2009
- The FAAH inhibitor URB-597 interferes with cisplatin- and nicotine-induced vomiting in the Suncus murinus (house musk shrew)Physiology & Behavior, 2009
- The antiemetic interaction of Δ9-tetrahydrocannabinol when combined with tropisetron or dexamethasone in the least shrewPharmacology Biochemistry and Behavior, 2009
- Δ9-Tetrahydrocannabinol suppresses vomiting behavior and Fos expression in both acute and delayed phases of cisplatin-induced emesis in the least shrewBehavioural Brain Research, 2009
- Why is the neurobiology of nausea and vomiting so important?Appetite, 2008
- Nabilone: An Effective Antiemetic in Patients Receiving Cancer ChemotherapyThe Journal of Clinical Pharmacology, 1981
- Superiority of Nabilone over Prochlorperazine as an Antiemetic in Patients Receiving Cancer ChemotherapyNew England Journal of Medicine, 1979