Dry Needling at Myofascial Trigger Spots of Rabbit Skeletal Muscles Modulates the Biochemicals Associated with Pain, Inflammation, and Hypoxia
Open Access
- 23 December 2012
- journal article
- research article
- Published by Hindawi Limited in Evidence-Based Complementary and Alternative Medicine
- Vol. 2012, 1-12
- https://doi.org/10.1155/2012/342165
Abstract
Background and Purpose. Dry needling is an effective therapy for the treatment of pain associated with myofascial trigger point (MTrP). However, the biochemical effects of dry needling that are associated with pain, inflammation, and hypoxia are unclear. This study investigated the activities of-endorphin, substance P, TNF-, COX-2, HIF-1, iNOS, and VEGF after different dosages of dry needling at the myofascial trigger spots (MTrSs) of a skeletal muscle in rabbit. Materials and Methods. Dry needling was performed either with one dosage (1D) or five dosages (5D) into the biceps femoris with MTrSs in New Zealand rabbits. Biceps femoris, serum, and dorsal root ganglion (DRG) were sampled immediately and 5 d after dry needling for-endorphin, substance P, TNF-, COX-2, HIF-1, iNOS, and VEGF immunoassays.Results. The 1D treatment enhanced the-endorphin levels in the biceps femoris and serum and reduced substance P in the biceps femoris and DRG. The 5D treatment reversed these effects and was accompanied by increase of TNF-, COX-2, HIF-1, iNOS, and VEGF production in the biceps femoris. Moreover, the higher levels of these biochemicals were still maintained 5 d after treatment.Conclusion. Dry needling at the MTrSs modulates various biochemicals associated with pain, inflammation, and hypoxia in a dose-dependent manner.
Funding Information
- National Science Council (NSC 100-2314-B241-001, NSC 101-2314-B241-001, CMU-100-S-07, CMU-101-S-35)
This publication has 51 references indexed in Scilit:
- The effect of dry needling in the treatment of myofascial pain syndrome: a randomized double-blinded placebo-controlled trialClinical Rheumatology, 2012
- Ancient Chinese medicine and mechanistic evidence of acupuncture physiologyPflügers Archiv - European Journal of Physiology, 2011
- Effects of low-level laser therapy on expression of TNF-α and TGF-β in skeletal muscle during the repair processLasers in Medical Science, 2010
- Dry Needling in the Management of Musculoskeletal PainThe Journal of the American Board of Family Medicine, 2010
- Laser Therapy for Myofascial PainCritical Reviews in Physical and Rehabilitation Medicine, 2010
- Nitric oxide and repair of skeletal muscle injuryNitric Oxide, 2009
- Research on Myofascial Pain SyndromeCritical Reviews in Physical and Rehabilitation Medicine, 2008
- Prevalence of Spontaneous Electrical Activity at Trigger Spots and at Control Sites in Rabbit Skeletal MuscleJournal of Musculoskeletal Pain, 1995
- Electrophysiological Characteristics of Localized Twitch Responses in Responsive Taut Bands of Rabbit Skeletal Muscle FibersJournal of Musculoskeletal Pain, 1994
- Ethical guidelines for investigations of experimental pain in conscious animalsPain, 1983