Flavonoids: A versatile source of anticancer drugs
Top Cited Papers
Open Access
- 1 January 2011
- journal article
- review article
- Published by EManuscript Technologies in Pharmacognosy Reviews
- Vol. 5 (9), 1-12
- https://doi.org/10.4103/0973-7847.79093
Abstract
An exponential increase in the number of studies investigating how different components of the diet interact at the molecular and cellular level to determine the fate of a cell has been witnessed. In search for anticancer drugs compelling data from laboratories, epidemiologic investigations, and human clinical trials showed that flavonoids have important effects on cancer chemoprevention and chemotherapy. In many molecular mechanisms of action for prevention against cancer, flavonoids play a major role by interacting between different types of genes and enzymes. Many mechanisms of action have been identified, including carcinogen inactivation, antiproliferation, cell cycle arrest, induction of apoptosis, inhibition of angiogenesis, antioxidation, and reversal of multidrug resistance or a combination of these mechanisms. This review focuses on the anticancer activity of flavonoids as well as their molecular mechanisms, including the treatment of mammary and prostate cancer. This review also highlights some advanced derivatives of flavonoids, which play an important role against cancer.Keywords
This publication has 110 references indexed in Scilit:
- Cancer chemoprevention with dietary phytochemicalsNature Reviews Cancer, 2003
- Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogensCarcinogenesis: Integrative Cancer Research, 2003
- Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current statusExpert Opinion on Investigational Drugs, 2000
- Constitutive activation of IκB kinase α and NF-κB in prostate cancer cells is inhibited by ibuprofenOncogene, 1999
- Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cellsEuropean Journal Of Cancer, 1998
- Molecular mechanisms in the antiproliferative action of quercetinLife Sciences, 1997
- Flavonoid-Mediated Tumor Growth Suppression Demonstrated by in vivo StudyCancer Biotherapy & Radiopharmaceuticals, 1996
- Isozyme- and species-specific susceptibility of cDNA-expressed CYP1A P-450s to different flavonoidsBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1994
- Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cellsLife Sciences, 1994
- Effect of catechins and citrus flavonoids on invasionin vitroClinical & Experimental Metastasis, 1991