Chromosome Aberrations and the Theory of RBE
- 1 January 1965
- journal article
- research article
- Published by Informa UK Limited in International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
- Vol. 9 (5), 477-502
- https://doi.org/10.1080/09553006514550551
Abstract
It is suggested that primary radiation damage to a macro-molecule in a cell which may lead to observable biological effect is normally the direct effect of a single energy-loss event in the marco-molecule. This concept is applied to the production of chromosome aberrations, regarding a local region of a chromosome as a molecule of DNA, and assuming that an aberration results from an exchange between 2 damaged regions. The model is consistent with the observed dependence aberration yield on dose, LET [Linear energy transfer] and modifying agents. Over a considerable range of LET, effectiveness per unit dose is proportional to dose-average LET. Similar basic concepts appear to be applicable to cell killing.This publication has 54 references indexed in Scilit:
- Lack of interaction of X-ray- and neutron-induced chromosome breaks in barleyMutation Research, 1965
- GENETIC DAMAGE AS A FUNCTION OF LETAnnals of the New York Academy of Sciences, 1964
- Oxygen Effect as an Explanation of Differences between the Action of α-Particles and X- or γ-Rays on Aqueous Solutions of Amino-acids and ProteinsNature, 1962
- X-Ray-Induced Chromosome Aberrations and Reproductive Death in Mammalian CellsThe American Naturalist, 1961
- The accurate estimation of chromatid breakage, and its relevance to a new interpretation of chromatid aberrations induced by ionizing radiationsProceedings of the Royal Society of London. Series B - Biological Sciences, 1959
- Interpretation of Induced Chromosome Breakage and RejoiningRadiation Research Supplement, 1959
- Factors Limiting the Number of Radiation-Induced Chromosome ExchangesThe Journal of cell biology, 1958
- The Modification of Damage Caused by Primary Ionization of Biological TargetsRadiation Research, 1956
- The Effect of Ionizing Radiations on the Broad Bean Root Part VIIIThe British Journal of Radiology, 1951
- Effect of Oxygen on the Frequency of Chromosome Aberrations Produced by X-RaysNature, 1947