Chlamydia trachomatis infection during pregnancy associated with preterm delivery: a population-based prospective cohort study
Open Access
- 3 May 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Journal of Epidemiology
- Vol. 26 (6), 493-502
- https://doi.org/10.1007/s10654-011-9586-1
Abstract
Chlamydia trachomatis infection is the most prevalent bacterial sexually transmitted infection and may influence pregnancy outcome. This study was conducted to assess the effect of chlamydial infection during pregnancy on premature delivery and birthweight. Pregnant women attending a participating midwifery practice or antenatal clinic between February 2003 and January 2005 were eligible for the study. From 4,055 women self-administered questionnaires and urine samples, tested by PCR, were analysed for C. trachomatis infection. Pregnancy outcomes were obtained from midwives and hospital registries. Gestational ages and birthweights were analysed for 3,913 newborns. The C. trachomatis prevalence was 3.9%, but varied by age and socio-economic background. Chlamydial infection was, after adjustment for potential confounders, associated with preterm delivery before 32 weeks (OR 4.35 [95% CI 1.3, 15.2]) and 35 weeks gestation (OR 2.66 [95% CI 1.1, 6.5]), but not with low birthweight. Of all deliveries before 32 weeks and 35 weeks gestation 14.9% [95% CI 4.5, 39.5] and 7.4% [95% CI 2.5, 20.1] was attributable to C. trachomatis infection. Chlamydia trachomatis infection contributes significantly to early premature delivery and should be considered a public health problem, especially in young women and others at increased risk of C. trachomatis infection.Keywords
This publication has 46 references indexed in Scilit:
- The Generation R Study: design and cohort update 2010European Journal of Epidemiology, 2010
- Chlamydia trachomatis as a Cause of Neonatal Conjunctivitis in Dutch InfantsPEDIATRICS, 2008
- The Generation R Study Biobank: a resource for epidemiological studies in children and their parentsEuropean Journal of Epidemiology, 2007
- Pregnancy outcomes in women infected with Chlamydia trachomatis: a population-based cohort study in Washington StateSexually Transmitted Infections, 2007
- A review on infection with Chlamydia trachomatisBest Practice & Research Clinical Obstetrics & Gynaecology, 2006
- Midpregnancy genitourinary tract infection with Chlamydia trachomatis: Association with subsequent preterm delivery in women with bacterial vaginosis and Trichomonas vaginalisAmerican Journal of Obstetrics and Gynecology, 2006
- Chlamydial infection and unplanned pregnancy in women with ready access to health careObstetrics & Gynecology, 2001
- The frequency and the role ofChlamydia trachomatisinfection in premature laborInternational Journal of Gynecology & Obstetrics, 1998
- Double-blind placebo-controlled treatment trial ofChlamydia trachomatis endocervical infections in pregnant womenInfectious Diseases in Obstetrics and Gynecology, 1997
- Maternal genitalChlamydia trachomatisinfection and the risk of preterm laborInternational Journal of Gynecology & Obstetrics, 1994