Obstetric Management of Loeys-Dietz Syndrome
- 1 June 2018
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Obstetrics & Gynecology
- Vol. 131 (6), 1080-1084
- https://doi.org/10.1097/aog.0000000000002615
Abstract
Loeys-Dietz syndrome is associated with arterial tortuosity and aortic dissection. Pregnancy may be a period of increased risk for aortic dissection. A 16-year-old primigravid girl was referred to our center with a family history of aortic dissection. Loeys-Dietz syndrome was suspected, and genetic testing confirmed the TGFβ2 (c.988C>T) mutation. A cesarean delivery was performed at 36 weeks of gestation, with no cardiovascular complications. In this case, the uterine vessels were significantly tortuous; this may be an additional finding in Loeys-Dietz syndrome. Women with Loeys-Dietz syndrome warrant special consideration in obstetric management secondary to the risk for aortic dissection. It is recommended that a multidisciplinary team with knowledge about connective tissue disorders and expertise in aortic surgery coordinate maternal obstetric and cardiovascular care.Keywords
This publication has 12 references indexed in Scilit:
- Atenolol versus Losartan in Children and Young Adults with Marfan's SyndromeThe New England Journal of Medicine, 2014
- Pregnancy Outcomes in Marfan Syndrome: A Retrospective Cohort StudyAmerican Journal of Perinatology, 2014
- Sex and gender differences in symptoms of myocardial ischaemiaEuropean Heart Journal, 2011
- ESC Guidelines on the management of cardiovascular diseases during pregnancy: The Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC)European Heart Journal, 2011
- Increased Vertebral Artery Tortuosity Index Is Associated With Adverse Outcomes in Children and Young Adults With Connective Tissue DisordersCirculation, 2011
- 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic DiseaseJournal of the American College of Cardiology, 2010
- Analysis of multigenerational families with thoracic aortic aneurysms and dissections due to TGFBR1 or TGFBR2 mutationsJournal of Medical Genetics, 2009
- Cardiovascular Problems in Pregnant Women With Marfan SyndromeCirculation, 2009
- The effect of beta-blocker therapy on clinical outcome in patients with Marfan's syndrome: A meta-analysisInternational Journal of Cardiology, 2007
- Aneurysm Syndromes Caused by Mutations in the TGF-β ReceptorThe New England Journal of Medicine, 2006