Understanding Signaling Cascades in Melanoma†
Open Access
- 17 December 2007
- journal article
- review article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 84 (2), 289-306
- https://doi.org/10.1111/j.1751-1097.2007.00254.x
Abstract
Understanding regulatory pathways involved in melanoma development and progression has advanced significantly in recent years. It is now appreciated that melanoma is the result of complex changes in multiple signaling pathways that affect growth control, metabolism, motility and the ability to escape cell death programs. Here we review the major signaling pathways currently known to be deregulated in melanoma with an implication to its development and progression. Among these pathways are Ras, B‐Raf, MEK, PTEN, phosphatidylinositol‐3 kinase (PI3Ks) and Akt which are constitutively activated in a significant number of melanoma tumors, in most cases due to genomic change. Other pathways discussed in this review include the [Janus kinase/signal transducer and activator of transcription (JAK/STAT), transforming growth factor‐β pathways which are also activated in melanoma, although the underlying mechanism is not yet clear. As a paradigm for remodeled signaling pathways, melanoma also offers a unique opportunity for targeted drug development.This publication has 271 references indexed in Scilit:
- Development of IFN-γ resistance is associated with attenuation of SOCS genes induction and constitutive expression of SOCS 3 in melanoma cellsBritish Journal of Cancer, 2007
- Rewired ERK-JNK Signaling Pathways in MelanomaCancer Cell, 2007
- JUN Oncogene Amplification and Overexpression Block Adipocytic Differentiation in Highly Aggressive SarcomasCancer Cell, 2007
- The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer typesBritish Journal of Cancer, 2007
- Dickkopf-1 activates cell death in MDA-MB435 melanoma cellsBiochemical and Biophysical Research Communications, 2007
- NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTENCell, 2007
- Exploiting the PI3K/AKT Pathway for Cancer Drug DiscoveryNature Reviews Drug Discovery, 2005
- Mutations of the BRAF gene in human cancerNature, 2002
- NF-κB in cancer: from innocent bystander to major culpritNature Reviews Cancer, 2002
- Hypoxia — a key regulatory factor in tumour growthNature Reviews Cancer, 2002