Faculty Opinions recommendation of Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial.

Abstract

This randomised trial in 6706 patients with atrial fibrillation and a high risk of stroke showed that oral anticoagulation therapy is superior to treatment with clopidogrel plus aspirin. This is an interesting new finding as atrial fibrillation patients were excluded from the CHARISMA trial {1}. The effect was even more pronounced in patients already taking oral anticoagulation at study entry.