Do Intestinal Hyperpermeability and the Related Food Antigens Play a Role in the Progression of IgA Nephropathy?

Abstract

Intestinal permeability was investigated by using ⁵¹Cr-EDTA as a probe molecule in 29 patients with immunoglobulin A nephropathy (IgA NP) and 20 healthy controls in 1990. Intestinal permeability was significantly higher in the IgA NP patients than in the controls (IgA NP, 3.86 ± 0.29%; controls, 2.72 ± 0.23%, p 3.2 g/l; n = 15) there was a significant correlation between serum IgA levels and the degree of intestinal permeability (p