Boron Units as Pharmacophores - New Applications and Opportunities of Boron Cluster Chemistry
- 1 January 2007
- journal article
- Published by Institute of Organic Chemistry & Biochemistry in Collection of Czechoslovak Chemical Communications
- Vol. 72 (12), 1646-1658
- https://doi.org/10.1135/cccc20071646
Abstract
Carboranes (dicarba-closo-dodecaboranes) are a class of carbon-containing polyhedral boron-cluster compounds showing remarkable hydrophobic character, chemical and thermal stability, and resistance to catabolism in biological environment. These features allow application of boron clusters as new hydrophobic core structure in biologically active molecules that interact hydrophobically with proteins, thus facilitating new drug design. A review with 45 references.Keywords
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