Synthesis of 9-Deoxynanaomycin a Methyl Ester1
- 1 April 1988
- journal article
- research article
- Published by Informa UK Limited in Synthetic Communications
- Vol. 18 (6), 597-605
- https://doi.org/10.1080/00397918808064017
Abstract
The tricyclic intermediate 6 prepared in three steps from 1,4-dimethoxynaphthalene was utilized in preparing alkene 7. Cleavage of the double bond of 7 furnished the keto aldehyde 9 which was transformed to the unsaturated ester 13. The ester 13 on heating with KOH-MeOH furnished the acid 14a whose methyl ester was oxidised to 9-deoxynanaomycin A methyl ester (2).Keywords
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