Assessment of Melamine and Cyanuric Acid Toxicity in Cats
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- 1 November 2007
- journal article
- research article
- Published by SAGE Publications in Journal of Veterinary Diagnostic Investigation
- Vol. 19 (6), 616-624
- https://doi.org/10.1177/104063870701900602
Abstract
The major pet food recall associated with acute renal failure in dogs and cats focused initially on melamine as the suspect toxicant. In the course of the investigation, cyanuric acid was identified in addition to melamine in the offending food. The purpose of this study was to characterize the toxicity potential of melamine, cyanuric acid, and a combination of melamine and cyanuric acid in cats. In this pilot study, melamine was added to the diet of 2 cats at 0.5% and 1%, respectively. Cyanuric acid was added to the diet of 1 cat at increasing doses of 0.2%, 0.5%, and 1% over the course of 10 days. Melamine and cyanuric acid were administered together at 0%, 0.2%, 0.5%, and 1% to 1 cat per dose group. No effect on renal function was observed in cats fed with melamine or cyanuric acid alone. Cats dosed with a combination were euthanized at 48 hours after dosing because of acute renal failure. Urine and touch impressions of kidneys from all cats dosed with the combination revealed the presence of fan-shaped, birefringent crystals. Histopathologic findings were limited to the kidneys and included crystals primarily within tubules of the distal nephron, severe renal interstitial edema, and hemorrhage at the corticomedullary junction. The kidneys contained estimated melamine concentrations of 496 to 734 mg/kg wet weight and estimated cyanuric acid concentrations of 487 to 690 mg/kg wet weight. The results demonstrate that the combination of melamine and cyanuric acid is responsible for acute renal failure in cats.Keywords
This publication has 16 references indexed in Scilit:
- Outbreaks of Renal Failure Associated with Melamine and Cyanuric Acid in Dogs and Cats in 2004 and 2007Journal of Veterinary Diagnostic Investigation, 2007
- Uric Acid and Renal DiseaseNucleosides, Nucleotides and Nucleic Acids, 2006
- Crystal-induced inflammation of the kidneys: results from human studies, animal models, and tissue-culture studiesClinical and Experimental Nephrology, 2004
- Pathophysiology, clinical consequences, and treatment of tumor lysis syndromeAmerican Journal Of Medicine, 2004
- Final Report on the Safety Assessment of Melamine/Formaldehyde ResinJournal of the American College of Toxicology, 1995
- A review of toxicology studies on cyanurate and its chlorinated derivatives.Environmental Health Perspectives, 1986
- Determination of cyanuric acid levels in swimming pool waters by u.v. absorbance, HPLC and melamine cyanurate precipitationWater Research, 1984
- Absorption and Excretion of Cyanuric Acid in Long-Distance SwimmersDrug Metabolism Reviews, 1982
- Chemical, bacteriological, and toxicological properties of cyanuric acid and chlorinated isocyanurates as applied to swimming pool disinfection: a review.American Journal of Public Health, 1974
- Toxicity of sodium cyanurateToxicology and Applied Pharmacology, 1965