Sample size re‐estimation in clinical trials
- 8 April 2009
- journal article
- review article
- Published by Wiley in Biometrical Journal
- Vol. 51 (2), 348-357
- https://doi.org/10.1002/bimj.200800266
Abstract
Adaptive clinical trials are becoming very popular because of their flexibility in allowing mid-stream changes of sample size, endpoints, populations, etc. At the same time, they have been regarded with mistrust because they can produce bizarre results in very extreme settings. Understanding the advantages and disadvantages of these rapidly developing methods is a must. This paper reviews flexible methods for sample size re-estimation when the outcome is continuous.Keywords
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