Dynamic control of TGF‐β signaling and its links to the cytoskeleton
- 28 March 2008
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 582 (14), 2051-2065
- https://doi.org/10.1016/j.febslet.2008.03.027
Abstract
Transforming growth factor beta (TGF-beta) regulates cellular behavior in embryonic and adult tissues. TGF-beta binding to serine/threonine kinase receptors on the plasma membrane activates Smad molecules and additional signaling proteins that coordinately regulate gene expression or cytoplasmic processes such as cytoskeletal dynamics. In turn, the activity and duration of the Smad pathway seems to be regulated by cytoskeletal components, which facilitate the shuttling process that segregates Smad proteins in the cytoplasm and nucleus. We discuss mechanisms and models that aim at explaining the coordination between several components of the signaling network downstream of the TGF-beta signal.Keywords
This publication has 144 references indexed in Scilit:
- Genome-wide Impact of the BRG1 SWI/SNF Chromatin Remodeler on the Transforming Growth Factor β Transcriptional ProgramPublished by Elsevier BV ,2008
- Integrating Patterning Signals: Wnt/GSK3 Regulates the Duration of the BMP/Smad1 SignalCell, 2007
- TGF-β activates Erk MAP kinase signalling through direct phosphorylation of ShcAThe EMBO Journal, 2007
- BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilinThe Journal of cell biology, 2007
- Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttlingBiochemical Journal, 2007
- TGFβ1 regulation of vimentin gene expression during differentiation of the C2C12 skeletal myogenic cell line requires Smads, AP-1 and Sp1 family membersBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2007
- TAK1 MAPK Kinase Kinase Mediates Transforming Growth Factor-β Signaling by Targeting SnoN Oncoprotein for DegradationPublished by Elsevier BV ,2007
- Smads orchestrate specific histone modifications and chromatin remodeling to activate transcriptionThe EMBO Journal, 2006
- Unique players in the BMP pathway: Small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signalingProceedings of the National Academy of Sciences of the United States of America, 2006
- Smad-dependent and Smad-independent pathways in TGF-β family signallingNature, 2003