Facile preparation of CF3-substituted carbinols with an azine donor and subsequent kinetic resolution through stereoselective Si–O coupling
- 18 August 2009
- journal article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 7 (21), 4464-4469
- https://doi.org/10.1039/b911534j
Abstract
A number of CF3-substituted carbinols decorated with an azine donor are efficiently prepared from fluoral and kinetically resolved in a reagent-controlled, Cu–H-catalysed Si–O coupling with a chiral silane. Selectivity factors are high, indicating a larger steric effect than CH3 or C6H5groups.Keywords
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