Plumbagin protects liver against fulminant hepatic failure and chronic liver fibrosis via inhibiting inflammation and collagen production

Abstract

// <![CDATA[ $('.header-date').hide();$('#titleAuthors').hide();$('#abstractHeader').hide(); // ]]> Huafeng Wang1, 2, 3, *, Huan Zhang1, 4, *, Yuqing Zhang5, *, Dan Wang1, *, Xixi Cheng1, Fengrui Yang1, 2, Qi Zhang1, Zhenyi Xue1, 2, Yan Li1, 2, Lijuan Zhang1, 2, Luhong Yang3, Guolin Miao1, 2, Daiqing Li6, Zhiyu Guan7, Yurong Da1, 2, Zhi Yao2, Fei Gao8, Liang Qiao9, Li Kong10, Rongxin Zhang1, 2 1Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, China 2Department of Immunology, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Immune Microenvironment and Diseases, Ministry of Education of China, Tianjin Medical University, Tianjin, China 3School of Life Science, Shanxi Normal University, Linfen, China 4Clinical Laboratory, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China 5Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, Nankai Clinical School of Medicine, Tianjin Medical University, Tianjin, China 6Key Laboratory of Hormones and Development (Ministry of Health), Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China 7Department of Pathogenic Biology, Weifang Medical University, Shandong, China 8State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China 9Storr Liver Unit, Westmead Millennium Institute, The Western Clinical School of the University of Sydney, Westmead, NSW, Australia 10Department of Histology and Embryology, Dalian Medical University, Dalian, China *These authors have contributed equally to this work Correspondence to: Rongxin Zhang, email: rxzhang@tmu.edu.cn, rongxinz@yahoo.com Li Kong, email: kongli@dmu.edu.cn Keywords: plumbagin, fulminant hepatic failure, liver fibrosis, hepatic stellate cell, inflammation Received: August 08, 2016 Accepted: October 04, 2016 Published: October 14, 2016