Infectious Prions in Pre-Clinical Deer and Transmission of Chronic Wasting Disease Solely by Environmental Exposure
Open Access
- 16 June 2009
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 4 (6), e5916
- https://doi.org/10.1371/journal.pone.0005916
Abstract
Key to understanding the epidemiology and pathogenesis of prion diseases, including chronic wasting disease (CWD) of cervids, is determining the mode of transmission from one individual to another. We have previously reported that saliva and blood from CWD-infected deer contain sufficient infectious prions to transmit disease upon passage into naïve deer. Here we again use bioassays in deer to show that blood and saliva of pre-symptomatic deer contain infectious prions capable of infecting naïve deer and that naïve deer exposed only to environmental fomites from the suites of CWD-infected deer acquired CWD infection after a period of 15 months post initial exposure. These results help to further explain the basis for the facile transmission of CWD, highlight the complexities associated with CWD transmission among cervids in their natural environment, emphasize the potential utility of blood-based testing to detect pre-clinical CWD infection, and could augur similar transmission dynamics in other prion infections.Keywords
This publication has 64 references indexed in Scilit:
- Genetic risk factors for variant Creutzfeldt–Jakob disease: a genome-wide association studyThe Lancet Neurology, 2009
- Detection of infectious prions in urineFEBS Letters, 2008
- Transmission and Detection of Prions in FecesThe Journal of Infectious Diseases, 2008
- Risk behaviors in a rural community with a known point-source exposure to chronic wasting diseaseEnvironmental Health, 2008
- PrP Sc in Salivary Glands of Scrapie-Affected SheepJournal of Virology, 2007
- Human Prion Disease and Relative Risk Associated with Chronic Wasting DiseaseEmerging Infectious Diseases, 2006
- Prion Infection of Oral and Nasal MucosaJournal of Virology, 2006
- Projections of the future course of the primary vCJD epidemic in the UK: inclusion of subclinical infection and the possibility of wider genetic susceptibilityJournal of The Royal Society Interface, 2005
- Prevalence of lymphoreticular prion protein accumulation in UK tissue samplesThe Journal of Pathology, 2004
- An analysis of natural scrapie in suffolk sheepHeredity, 1965