Clinical evaluation of outdoor cats exposed to ectoparasites and associated risk for vector-borne infections in southern Italy
Open Access
- 20 March 2018
- journal article
- research article
- Published by Springer Science and Business Media LLC in Parasites & Vectors
- Vol. 11 (1), 1-11
- https://doi.org/10.1186/s13071-018-2725-8
Abstract
Background: Cats can be carriers of infected arthropods and be infected with several vector-borne pathogens (VBP) but there is limited knowledge about their pathogenic role in cats. Results: A cross-sectional controlled study investigated the clinical status and antibody (Bartonella henselae, Rickettsia conorii, Ehrlichia canis, Anaplasma phagocytophilum, Babesia microti and Leishmania infantum) and/or blood PCR (Mycoplasma spp., Bartonella spp., Rickettsia spp., Ehrlichia/Anaplasma spp., piroplasmids, L. infantum, Hepatozoon felis) prevalence in 197 cats. Outdoor cats lacking ectoparasiticide treatment or hosting ectoparasites (study group [SG], n = 134) and indoor cats treated against ectoparasites (control group [CG], n = 63) were enrolled. Clinical data and retroviral co-infections were compared between the two groups. Multivariable analysis tested associations between variables and VBP exposure. Lymphadenia, stomatitis, and various haematological abnormalities were statistically more frequent in SG. Antibodies against R. conorii, B. henselae, A. phagocytophylum, B. microti, E. canis and L. infantum were detected. Bartonella henselae, Bartonella clarridgeiae, Mycoplasma haemofelis, "Candidatus Mycoplasma haemominutum" and "Candidatus Mycoplasma turicensis" DNA were identified. Very high antibody (87.8%) and PCR (40.1%) positivity to at least one pathogen were detected and were significantly higher in SG. Co-infections were confirmed in about one-third of the cats and were more frequent in SG cats. Molecular and overall (antibody and PCR) positivity to Bartonella and antibody positivity to R. conorii were higher in SG. Multivariable analysis found significant associations of Bartonella spp. infection with Feline Immunodeficiency Virus (FIV) infection and increased globulins, and of Mycoplasma spp. infection with adult age, FIV infection, anaemia, and increased creatinine. Conclusions: A very high prevalence of exposure to zoonotic VBP was found in cats, with Rickettsia and Bartonella infections being most prevalent. Some risk factors were documented namely for Mycoplasma spp. and Bartonella spp. The lifestyle of cats is clinically relevant and requires specific preventative measures to protect their health.Keywords
Funding Information
- Bayer HealthCare
This publication has 54 references indexed in Scilit:
- First clinical case report of Cytauxzoon sp. infection in a domestic cat in France.BMC Veterinary Research, 2017
- Prevalence study and risk factor analysis of selected bacterial, protozoal and viral, including vector-borne, pathogens in cats from CyprusParasites & Vectors, 2017
- Intestinal parasites and vector-borne pathogens in stray and free-roaming cats living in continental and insular GreecePLoS Neglected Tropical Diseases, 2017
- First report of Cytauxzoon sp. infection in a domestic cat from PortugalParasites & Vectors, 2016
- Cell tropism and molecular epidemiology of Anaplasma platys-like strains in catsTicks and Tick-borne Diseases, 2015
- The role of cats in the eco-epidemiology of spotted fever group diseasesParasites & Vectors, 2014
- Bartonella Species Antibodies and Hyperglobulinemia in Privately Owned CatsJournal of Veterinary Internal Medicine, 2012
- Serology, PCR and culture of Ehrlichia/Anaplasma species in asymptomatic and symptomatic cats from central SpainClinical Microbiology & Infection, 2009
- Transmission of Leishmania infantum via blood transfusion in dogs: Potential for infection and importance of clinical factorsVeterinary Parasitology, 2006
- Transmission of visceral leishmaniasis through blood transfusions from infected English Foxhounds to anemic dogsJournal of the American Veterinary Medical Association, 2001