Interleukin 18 in the CNS
Open Access
- 29 January 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Journal of Neuroinflammation
- Vol. 7 (1), 9
- https://doi.org/10.1186/1742-2094-7-9
Abstract
Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavior. Work on IL-18 null mice, the localization of the IL-18 receptor complex in neurons and the neuronal expression of decoy isoforms of the receptor subunits are beginning to reveal the complexity and the significance of the IL-18 system in the CNS. This review summarizes current knowledge on the central role of IL-18 in health and disease.This publication has 145 references indexed in Scilit:
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