Clinical evaluation of an HP-guar gellable lubricant eye drop for the relief of dryness of the eye
- 1 January 2004
- journal article
- clinical trial
- Published by Informa UK Limited in Current Eye Research
- Vol. 28 (1), 55-62
- https://doi.org/10.1076/ceyr.28.1.55.23495
Abstract
Purpose. To evaluate the efficacy of a new lubricant eye drop containing polyethylene glycol 400 and propylene glycol demulcents with hydroxypropyl-guar as a gelling agent (Test Product) to a system with carboxymethylcellulose (Control Product) for reducing dry eye signs and symptoms. Methods. Eighty-seven dry eye volunteers were enrolled at seven sites for this six-week, concurrently controlled, double-masked clinical study. Results. The Test Product significantly reduced conjunctival staining (p = 0.025) and temporal corneal staining (p = 0.024) compared to the Control. The Test Product also significantly reduced symptoms of dryness in the morning and evening, compared to the Control (p = 0.015 and p = 0.023, respectively). Subjects in the Test treatment group reported lower frequencies of foreign body sensation and felt their eyes were “refreshed longer” compared to those in the Control group (p = 0.033 and p = 0.037, respectively). Conclusions. The Test Product was more effective at reducing both the signs and symptoms of dry eye compared to the carboxymethylcellulose containing Control.Keywords
This publication has 6 references indexed in Scilit:
- Challenges and Pitfalls in Clinical Trials of Treatments for Dry EyeThe Ocular Surface, 2003
- Use of the Dry Eye Questionnaire to Measure Symptoms of Ocular Irritation in Patients With Aqueous Tear Deficient Dry EyeCornea, 2002
- Epithelial Mucins of the Ocular Surface: Structure, Biosynthesis and FunctionExperimental Eye Research, 2001
- A Patient Questionnaire Approach to Estimating the Prevalence of Dry Eye Symptoms in Patients Presenting to Optometric Practices across CanadaOptometry and Vision Science, 1997
- Tear film profile in dry eyeActa Ophthalmologica, 1991
- Tear physiology and dry eyesSurvey of Ophthalmology, 1977