New Experimental Models of Diabetic Nephropathy in Mice Models of Type 2 Diabetes: Efforts to Replicate Human Nephropathy
Open Access
- 8 February 2012
- journal article
- review article
- Published by Hindawi Limited in Experimental Diabetes Research
- Vol. 2012, 1-9
- https://doi.org/10.1155/2012/616313
Abstract
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. The use of experimental models of DN has provided valuable information regarding many aspects of DN, including pathophysiology, progression, implicated genes, and new therapeutic strategies. A large number of mouse models of diabetes have been identified and their kidney disease was characterized to various degrees. Most experimental models of type 2 DN are helpful in studying early stages of DN, but these models have not been able to reproduce the characteristic features of more advanced DN in humans such as nodules in the glomerular tuft or glomerulosclerosis. The generation of new experimental models of DN created by crossing, knockdown, or knockin of genes continues to provide improved tools for studying DN. These models provide an opportunity to search for new mechanisms involving the development of DN, but their shortcomings should be recognized as well. Moreover, it is important to recognize that the genetic background has a substantial effect on the susceptibility to diabetes and kidney disease development in the various models of diabetes.Keywords
This publication has 53 references indexed in Scilit:
- BTBR Ob/Ob Mutant Mice Model Progressive Diabetic NephropathyJournal of the American Society of Nephrology, 2010
- Transgenic overexpression of GLUT1 in mouse glomeruli produces renal disease resembling diabetic glomerulosclerosisAmerican Journal of Physiology-Renal Physiology, 2010
- Decorin Deficiency Enhances Progressive Nephropathy in Diabetic MiceThe American Journal of Pathology, 2007
- Glomerular Localization and Expression of Angiotensin-Converting Enzyme 2 and Angiotensin-Converting EnzymeJournal of the American Society of Nephrology, 2006
- Endothelial Nitric Oxide Synthase Deficiency Produces Accelerated Nephropathy in Diabetic MiceJournal of the American Society of Nephrology, 2006
- Nodular glomerulosclerosis mimicking diabetic nephropathy without overt diabetes mellitusClinical Nephrology, 2005
- Lifelong genetic minipumpsPhysiological Genomics, 2005
- Microvasculature of Hydronephrotic Kidneys in KK-Ay Mice.The Journal of Veterinary Medical Science, 2000
- Interaction Between BTBR and C57BL/6J Genomes Produces an Insulin Resistance Syndrome in (BTBR × C57BL/6J) F 1 MiceArteriosclerosis, Thrombosis, and Vascular Biology, 1997
- Abnormal splicing of the leptin receptor in diabetic miceNature, 1996