The Formamidopyrimidines: Purine Lesions Formed in Competition With 8-Oxopurines From Oxidative Stress
Open Access
- 11 November 2011
- journal article
- review article
- Published by American Chemical Society (ACS) in Accounts of Chemical Research
- Vol. 45 (4), 588-597
- https://doi.org/10.1021/ar2002182
Abstract
DNA is constantly exposed to agents that induce structural damage, from sources both internal and external to an organism. Endogenous species, such as oxidizing chemicals, and exogenous agents, such as ultraviolet rays in sunlight, together produce more than 70 distinct chemical modifications of native nucleotides. Of these, about 15 of the lesions have been detected in cellular DNA. This kind of structural DNA damage can be cytotoxic, carcinogenic, or both, and is being linked to an increasingly lengthy list of diseases.Keywords
This publication has 56 references indexed in Scilit:
- Bypass of Aflatoxin B1 Adducts by the Sulfolobus solfataricus DNA Polymerase IVJournal of the American Chemical Society, 2011
- Novel post-synthetic generation, isomeric resolution, and characterization of Fapy-dG within oligodeoxynucleotides: differential anomeric impacts on DNA duplex propertiesNucleic Acids Research, 2011
- Nanopore Detection of 8-Oxo-7,8-dihydro-2′-deoxyguanosine in Immobilized Single-Stranded DNA via Adduct Formation to the DNA Damage SiteJournal of the American Chemical Society, 2010
- HO • radicals induce an unexpected high proportion of tandem base lesions refractory to repair by DNA glycosylasesProceedings of the National Academy of Sciences of the United States of America, 2010
- Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylaseProceedings of the National Academy of Sciences of the United States of America, 2009
- Site-Specific Synthesis and Characterization of Oligonucleotides Containing an N6-(2-Deoxy-d-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine Lesion, the Ring-Opened Product from N7-Methylation of DeoxyguanosineChemical Research in Toxicology, 2008
- DNA polymerase bypass in vitro and in E. coli of a C-nucleotide analogue of Fapy·dGBioorganic & Medicinal Chemistry, 2008
- Facile Quantification of Lesions Derived from 2‘-Deoxyguanosine in DNAJournal of the American Chemical Society, 2007
- Synthesis, DNA Polymerase Incorporation, and Enzymatic Phosphate Hydrolysis of Formamidopyrimidine Nucleoside TriphosphatesJournal of the American Chemical Society, 2006
- Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cellsNucleic Acids Research, 2006