Prostanoid EP4Receptor Stimulation Produces Ocular Hypotension by a Mechanism That Does Not Appear to Involve Uveoscleral Outflow

Abstract

Purpose. As part of a systematic elucidation of the pharmacology of prostaglandin’s (PG) effects on intraocular pressure in the monkey, the prototypical selective prostanoid EP₄ receptor agonist (3,7-dithia PGE₁) was examined. It was found to be highly efficacious in nonhuman primates, and its mechanism of ocular hypotensive activity was investigated.