Excess Mortality, Causes of Death and Life Expectancy in 270,770 Patients with Recent Onset of Mental Disorders in Denmark, Finland and Sweden
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Open Access
- 25 January 2013
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (1), e55176
- https://doi.org/10.1371/journal.pone.0055176
Abstract
Excess mortality among patients with severe mental disorders has not previously been investigated in detail in large complete national populations. To investigate the excess mortality in different diagnostic categories due to suicide and other external causes of death, and due to specific causes in connection with diseases and medical conditions. In longitudinal national psychiatric case registers from Denmark, Finland, and Sweden, a cohort of 270,770 recent-onset patients, who at least once during the period 2000 to 2006 were admitted due to a psychiatric disorder, were followed until death or the end of 2006. They were followed for 912,279 person years, and 28,088 deaths were analyzed. Life expectancy and standardized cause-specific mortality rates were estimated in each diagnostic group in all three countries. The life expectancy was generally approximately 15 years shorter for women and 20 years shorter for men, compared to the general population. Mortality due to diseases and medical conditions was increased two- to three-fold, while excess mortality from external causes ranged from three- to 77-fold. Mortality due to diseases and medical conditions was generally lowest in patients with affective disorders and highest in patients with substance abuse and personality disorders, while mortality due to suicide was highest in patients with affective disorders and personality disorders, and mortality due to other external causes was highest in patients with substance abuse. These alarming figures call for action in order to prevent the high mortality.Keywords
This publication has 50 references indexed in Scilit:
- The Danish Psychiatric Central Research RegisterScandinavian Journal of Public Health, 2011
- Early risk factors for suicide in an epidemiological first episode psychosis cohortSchizophrenia Research, 2011
- Review: Inequalities in healthcare provision for people with severe mental illnessJournal of Psychopharmacology, 2010
- Commitment to coercive care in relation to substance abuse reports to the social services. A 2-year follow-upNordic Journal of Psychiatry, 2010
- Impact of a nurse-led intervention to improve screening for cardiovascular risk factors in people with severe mental illnesses. Phase-two cluster randomised feasibility trial of community mental health teamsBMC Health Services Research, 2010
- The 2009 Schizophrenia PORT Psychosocial Treatment Recommendations and Summary StatementsSchizophrenia Bulletin, 2009
- Cardiovascular disease and diabetes in people with severe mental illness position statement from the European Psychiatric Association (EPA), supported by the European Association for the Study of Diabetes (EASD) and the European Society of Cardiology (ESC)European Psychiatry, 2009
- Antipsychotic effects on estimated 10-year coronary heart disease risk in the CATIE schizophrenia studySchizophrenia Research, 2008
- A Systematic Review of Mortality in SchizophreniaArchives of General Psychiatry, 2007
- Excess mortality of schizophreniaThe British Journal of Psychiatry, 1997