The neural basis of nonvisual object recognition memory in the rat.
Open Access
- 1 February 2013
- journal article
- Published by American Psychological Association (APA) in Behavioral Neuroscience
- Vol. 127 (1), 70-85
- https://doi.org/10.1037/a0031216
Abstract
Research into the neural basis of recognition memory has traditionally focused on the remembrance of visual stimuli. The present study examined the neural basis of object recognition memory in the dark, with a view to determining the extent to which it shares common pathways with visual-based object recognition. Experiment 1 assessed the expression of the immediate-early gene c-fos in rats that discriminated novel from familiar objects in the dark (Group Novel). Comparisons made with a control group that explored only familiar objects (Group Familiar) showed that Group Novel had higher c-fos activity in the rostral perirhinal cortex and the lateral entorhinal cortex. Outside the temporal region, Group Novel showed relatively increased c-fos activity in the anterior medial thalamic nucleus and the anterior cingulate cortex. Both the hippocampal CA fields and the granular retrosplenial cortex showed borderline increases in c-fos activity with object novelty. The hippocampal findings prompted Experiment 2. Here, rats with hippocampal lesions were tested in the dark for object recognition memory at different retention delays. Across two replications, no evidence was found that hippocampal lesions impair nonvisual object recognition. The results indicate that in the dark, as in the light, interrelated parahippocampal sites are activated when rats explore novel stimuli. These findings reveal a network of linked c-fos activations that share superficial features with those associated with visual recognition but differ in the fine details; for example, in the locus of the perirhinal cortex activation. While there may also be a relative increase in c-fos activation in the extended-hippocampal system to object recognition in the dark, there was no evidence that this recognition memory problem required an intact hippocampus.Keywords
Funding Information
- Wellcome Trust (WT087855)
This publication has 65 references indexed in Scilit:
- Contrasting brain activity patterns for item recognition memory and associative recognition memory: Insights from immediate-early gene functional imagingNeuropsychologia, 2012
- Borders and cytoarchitecture of the perirhinal and postrhinal cortices in the ratJournal of Comparative Neurology, 2001
- Rats with lesions of the hippocampus are impaired on the delayed nonmatching‐to‐sample task†Hippocampus, 2001
- Recognition memory: What are the roles of the perirhinal cortex and hippocampus?Nature Reviews Neuroscience, 2001
- Neural substrates of crossmodal association memory in monkeys: The amygdala versus the anterior rhinal cortex.Behavioral Neuroscience, 2001
- Impaired Recognition Memory in Rats after Damage to the HippocampusJournal of Neuroscience, 2000
- Fos expression in the rostral thalamic nuclei and associated cortical regions in response to different spatial memory testsNeuroscience, 2000
- Neural Correlates of Olfactory Recognition Memory in the Rat Orbitofrontal CortexJournal of Neuroscience, 2000
- Fos Imaging Reveals Differential Patterns of Hippocampal and Parahippocampal Subfield Activation in Rats in Response to Different Spatial Memory TestsJournal of Neuroscience, 2000
- Perirhinal cortex input to the hippocampus in the rat: evidence for parallel pathways, both direct and indirect. A combined physiological and anatomical studyEuropean Journal of Neuroscience, 1999