Assessing exposure in epidemiologic studies to disinfection by-products in drinking water: report from an international workshop.
Open Access
- 1 February 2002
- journal article
- review article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 110 (suppl 1), 53-60
- https://doi.org/10.1289/ehp.02110s153
Abstract
The inability to accurately assess exposure has been one of the major shortcomings of epidemiologic studies of disinfection by-products (DBPs) in drinking water. A number of contributing factors include a) limited information on the identity, occurrence, toxicity, and pharmacokinetics of the many DBPs that can be formed from chlorine, chloramine, ozone, and chlorine dioxide disinfection; b) the complex chemical interrelationships between DBPs and other parameters within a municipal water distribution system; and c) difficulties obtaining accurate and reliable information on personal activity and water consumption patterns. In May 2000, an international workshop was held to bring together various disciplines to develop better approaches for measuring DBP exposure for epidemiologic studies. The workshop reached consensus about the clear need to involve relevant disciplines (e.g., chemists, engineers, toxicologists, biostatisticians and epidemiologists) as partners in developing epidemiologic studies of DBPs in drinking water. The workshop concluded that greater collaboration of epidemiologists with water utilities and regulators should be encouraged in order to make regulatory monitoring data more useful for epidemiologic studies. Similarly, exposure classification categories in epidemiologic studies should be chosen to make results useful for regulatory or policy decision making.Keywords
This publication has 38 references indexed in Scilit:
- Exposure to tap water during pregnancyJournal of Exposure Science & Environmental Epidemiology, 2001
- Assessing exposure to disinfection by-products in women of reproductive age living in Corpus Christi, Texas, and Cobb county, Georgia: descriptive results and methods.Environmental Health Perspectives, 2001
- Evaluation of Biomarkers of Environmental Exposures: Urinary Haloacetic Acids Associated with Ingestion of Chlorinated Drinking WaterEnvironmental Research, 1999
- Exposure estimates to disinfection by-products of chlorinated drinking water.Environmental Health Perspectives, 1999
- A Physiologically Based Pharmacokinetic Description of the Oral Uptake, Tissue Dosimetry, and Rates of Metabolism of Bromodichloromethane in the Male RatToxicology and Applied Pharmacology, 1998
- Alveolar breath sampling and analysis to assess trihalomethane exposures during competitive swimming training.Environmental Health Perspectives, 1997
- GlutathioneS-Transferase-Mediated Mutagenicity of Trihalomethanes inSalmonella typhimurium:Contrasting Results with Bromodichloromethane and ChloroformToxicology and Applied Pharmacology, 1997
- Reproductive and developmental effects of disinfection by-products in drinking water.Environmental Health Perspectives, 1996
- Ingestion, inhalation, and dermal exposures to chloroform and trichloroethene from tap water.Environmental Health Perspectives, 1996
- Effect of Bromide Ion on Haloacetic Acid Speciation Resulting from Chlorination and Chloramination of Aquatic Humic SubstancesEnvironmental Science & Technology, 1995