Prevalence of High-risk Nonavalent Vaccine-type Human Papillomavirus Infection Among Unvaccinated, Sexually Active Asian Female Adolescents With and Without Perinatally Acquired HIV Infection
- 1 July 2020
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in The Pediatric Infectious Disease Journal
- Vol. 39 (7), 615-619
- https://doi.org/10.1097/INF.0000000000002659
Abstract
Background: We studied the prevalence of 7, high-risk human papillomavirus (HPV) types in the nonavalent vaccine (HRVT-7: HPV 16, 18, 31, 33, 45, 52, 58) among vaccine-naive, sexually active Asian female adolescents with and without perinatally acquired HIV infection (PHIV). Methods: PHIV female adolescents 12-24 years of age and HIV-uninfected controls matched by age and number of lifetime sex partners were enrolled in a 3-year observational cohort study in Thailand and Vietnam. Samples from the oral cavity, anus, cervix and vagina were collected for HRVT-7 HPV genotyping, and serum collected for HPV 16 and 18 antibody testing. Baseline data were analyzed using multivariable logistic regression. Results: We included 93 PHIV (median CD4 593 cells/mm(3), 62% with HIV RNA suppression) and 99 HIV-uninfected adolescents (median lifetime sex partners 2). The overall prevalence of HRVT-7 infection was 53% in PHIV and 49% in HIV-uninfected adolescents (P= 0.66). Cervical HRVT-7 DNA was detected more frequently in PHIV than HIV-uninfected adolescents (37% vs. 23%,P= 0.04). Overall, more lifetime partners [>= 3 vs. 1; odds ratio (OR) 2.99 (1.38-6.51),P= 0.02] and having other sexually transmitted infections [OR 3.30 (1.51-7.21),P= 0.003] increased the risk of HRVT-7 infection and/or positive HPV 16/18 antibodies; while detectable HIV RNA [OR 2.78 (1.05-7.36),P= 0.04] increased the risk among PHIV adolescents. Conclusions: Half of sexually active Asian female adolescents, regardless of HIV infection, had already acquired HRVT-7 infection. This underscores the need for earlier access to HPV vaccine in the region.Keywords
This publication has 16 references indexed in Scilit:
- Human papillomavirus infection among male adolescents and young adults with perinatally-acquired HIV and without HIV in ThailandInternational Journal of STD & AIDS, 2019
- Risk Factors for Human Papillomavirus Infection and Abnormal Cervical Cytology Among Perinatally Human Immunodeficiency Virus-Infected and Uninfected Asian YouthClinical Infectious Diseases, 2018
- HIV-positive women have higher risk of human papilloma virus infection, precancerous lesions, and cervical cancerAIDS, 2018
- Human papillomavirus vaccines: WHO position paper, May 2017–RecommendationsVaccine, 2017
- Worldwide burden of cancer attributable to HPV by site, country and HPV typeInternational Journal of Cancer, 2017
- Monitoring the impact of HPV vaccine in males—Considerations and challengesPapillomavirus Research, 2016
- Prevalence and Risk Factors for HPV in HIV-Positive Young Women Receiving Their First HPV VaccinationJAIDS Journal of Acquired Immune Deficiency Syndromes, 2012
- HIV, human papillomavirus, and cervical neoplasia and cancer in the era of highly active antiretroviral therapyEuropean Journal Of Cancer Prevention, 2008
- Persistence of Human Papillomavirus Infection in HIV‐Infected and ‐Uninfected Adolescent Girls: Risk Factors and Differences, by Phylogenetic TypeThe Journal of Infectious Diseases, 2004
- Reactivity of human sera in a sensitive, high-throughput pseudovirus-based papillomavirus neutralization assay for HPV16 and HPV18Virology, 2004