Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis
Open Access
- 1 December 2000
- journal article
- Published by Elsevier BV
- Vol. 275 (50), 39262-39266
- https://doi.org/10.1074/jbc.c000622200
Abstract
No abstract availableKeywords
This publication has 40 references indexed in Scilit:
- The Role of Actin-binding Protein 280 in Integrin-dependent MechanoprotectionPublished by Elsevier BV ,1998
- Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family ProteasesImmunity, 1997
- Human Perforin: Rapid Enrichment by Immobilized Metal Affinity Chromatography (IMAC) for Whole Cell Cytotoxicity AssaysBiochemical and Biophysical Research Communications, 1996
- Granzyme B/Perforin-Mediated Apoptosis of Jurkat Cells Results in Cleavage of Poly(ADP-ribose) Polymerase to the 89-kDa Apoptotic Fragment and Less Abundant 64-kDa FragmentBiochemical and Biophysical Research Communications, 1996
- Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell DeathCell, 1996
- Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient miceNature, 1994
- Immunopurification of Functional Asp-ase (Natural Killer Cell Granzyme B) Using a Monoclonal AntibodyBiochemical and Biophysical Research Communications, 1993
- Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.The Journal of Experimental Medicine, 1992
- A natural killer cell granule protein that induces DNA fragmentation and apoptosis.The Journal of Experimental Medicine, 1992
- Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring.The Journal of cell biology, 1990