Changing Global Epidemiology of Inflammatory Bowel Diseases: Sustaining Health Care Delivery Into the 21st Century
- 30 January 2020
- journal article
- review article
- Published by Elsevier BV in Clinical Gastroenterology and Hepatology
- Vol. 18 (6), 1252-1260
- https://doi.org/10.1016/j.cgh.2020.01.028
Abstract
Crohn’s disease (CD) and ulcerative colitis (UC) have emerged as global diseases. They affect over 2 million individuals in the North America, 3.2 million in Europe, and millions more worldwide. The recent decades have been characterized by several important changes in the epidemiology of these diseases, in particularly an increasing incidence rates in newly industrialized countries experiencing a westernization of lifestyle. While rates of surgery have experienced a temporal decline attributable in part to increasing availability of medical treatments, earlier initiation of effective therapy, and changes in clinical practice, the healthcare costs associated with these diseases have continued to increase, in part due to costly therapies. Robust epidemiologic and experimental studies have defined the role of the external environment and microbiome on disease pathogenesis and have offered opportunities for disease prevention by modifying such factors. We propose several important steps that are necessary to provide globally sustainable IBD care in the 21st century.Keywords
This publication has 71 references indexed in Scilit:
- A nationwide population-based study of the inflammatory bowel diseases between 1998 and 2008 in TaiwanBMC Gastroenterology, 2013
- Population‐based cases control study of inflammatory bowel disease risk factorsJournal of Gastroenterology and Hepatology, 2010
- Direct Health Care Costs of Crohn's Disease and Ulcerative Colitis in US Children and AdultsGastroenterology, 2008
- Increased Immune Reactivity Predicts Aggressive Complicating Crohn's Disease in ChildrenClinical Gastroenterology and Hepatology, 2008
- The incidence of Crohn’s disease in Cardiff over the last 75 years: an update for 1996–2005Alimentary Pharmacology & Therapeutics, 2007
- The origins of the developmental origins theoryJournal of Internal Medicine, 2007
- Cost Analysis and Cost Determinants in a European Inflammatory Bowel Disease Inception Cohort With 10 Years of Follow-up EvaluationGastroenterology, 2006
- Ulcerative colitis in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survivalGut, 2000
- Prevalence and family risk of ulcerative colitis and Crohn's disease: an epidemiological study among Europeans and south Asians in Leicestershire.Gut, 1993
- Inflammatory Bowel DiseaseJournal of Clinical Gastroenterology, 1992