Oral lichen planus: an overview
- 1 June 2004
- journal article
- review article
- Published by Informa UK Limited in Journal of Dermatological Treatment
- Vol. 15 (3), 136-140
- https://doi.org/10.1080/09546630410030720
Abstract
Lichen planus (LP) is a chronic inflammatory muco-cutaneous disease. Since disorders of NK-cell functional activity could be observed in patients with LP, it is considered to be an autoimmune disease. The pathogenesis of LP is complex and not completely understood. The involvement of mucous membranes is frequently seen, usually asymptomatic, but occasionally complicated by extensive painful erosions, causing a considerable loss of quality of life. Patients with symptomatic oral lichen planus (OLP) often require intensive therapy to reduce the signs and symptoms of this painful and disabling inflammatory disease. OLP is considered to be a precancerous lesion for the development of squamous cell carcinomas. OLP is highly resistant to topical treatment and tends to pursue a chronic course with little tendency to spontaneous resolution. Until now meta-analysis provided little evidence for the superiority of the assessed interventions over placebo for palliation of symptomatic OLP.Keywords
This publication has 34 references indexed in Scilit:
- Pimecrolimus in an adhesive ointment as a new treatment option for oral lichen planusBritish Journal of Dermatology, 2004
- Oral mucosal keratinocytes express RANTES and ICAM-1, but not interleukin-8, in oral lichen planus and oral lichenoid reactions induced by amalgam fillingsClinical and Experimental Dermatology, 2003
- Oral lichen planus: Causes, diagnosis and managementAustralian Dental Journal, 2002
- Oral lichen planus pathogenesis: A role for the HCV-specific cellular immune responseHepatology, 2002
- Oral lichen planus: a preliminary clinical study on treatment with tazaroteneOral Diseases, 2002
- Azathioprine for the Treatment of Severe Erosive Oral and Generalized Lichen PlanusPublished by Medical Journals Sweden AB ,2001
- Successful treatment of lichen planus with lowmolecular-weight heparin: a case series of seven patientsJournal of Dermatological Treatment, 2001
- CorrespondenceInternational Journal of Dermatology, 2000
- Dramatic response to levamisole and low-dose prednisolone in 23 patients with oral lichen planus: A 6-year prospective follow-up studyOral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 1995
- Hydroxychloroquine sulfate (Plaquenil) improves oral lichen planus: An open trialJournal of the American Academy of Dermatology, 1993