Long-Term Effects of Indomethacin Prophylaxis in Extremely-Low-Birth-Weight Infants
Open Access
- 28 June 2001
- journal article
- clinical trial
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 344 (26), 1966-1972
- https://doi.org/10.1056/nejm200106283442602
Abstract
The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage in very-low-birth-weight infants (those with birth weights below 1500 g). Whether prophylaxis with indomethacin confers any long-term benefits that outweigh the risks of drug-induced reductions in renal, intestinal, and cerebral blood flow is not known.Keywords
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