Treatment of Invasive Bladder Cancer by Local Resection and High Dose Methotrexate
- 1 December 1984
- journal article
- Published by Wiley in British Journal of Urology
- Vol. 56 (6), 668-672
- https://doi.org/10.1111/j.1464-410x.1984.tb06142.x
Abstract
Fifty-seven patients with transitional cell carcinoma of the bladder, categories pT2, pT3a and pT3b, were treated by transurethral resection of the tumour mass (54 cases) or partial cystectomy (3 cases) followed by 8 doses of methotrexate 2 g i.v. every 3 weeks with appropriate Leucovorin rescue. At completion of chemotherapy 6 months after TUR 33/57 patients were tumour-free; 5/57 had new superficial tumours; 13/57 had persistent tumour invading muscle, 3 showed tumour progression and 3 had died from treatment complications. One-year survival was 45/57 (82%); 2-year survival was 23/39. Although some patients developed metastases and others have grown new superficial tumours, of those surviving, the bladder was free of the original invasive tumour in 38/45 (84%) at 1 year and in 19/24 (79%) at 2 years. It is concluded that transurethral resection plus high dose methotrexate may offer an effective alternative to radiotherapy or cystectomy for a significant proportion of patients with invasive bladder cancer.Keywords
This publication has 4 references indexed in Scilit:
- Adjuvant Chemotherapy with Doxorubicin (Adriamycin) and 5–Fluorouracil in T3, NX, MO Bladder Cancer Treated with RadiotherapyBritish Journal of Urology, 1983
- Treatment of T3 Bladder Cancer: Controlled Trial of Pre-operative Radiotherapy and Radical Cystectomy Versus Radical Radiotherapy: Second Report and Review (for the Clinical Trials Group, Institute of Urology)British Journal of Urology, 1982
- Combined Surgery and Adjuvant Chemotherapy with High Dose Methotrexate and Folinic Acid Rescue (HDMTX-CF) for Infiltrating Tumours of the BladderBritish Journal of Urology, 1981