Perfluorinated Compounds in Human Breast Milk from Several Asian Countries, and in Infant Formula and Dairy Milk from the United States
- 11 October 2008
- journal article
- research article
- Published by American Chemical Society (ACS) in Environmental Science & Technology
- Vol. 42 (22), 8597-8602
- https://doi.org/10.1021/es801875v
Abstract
The occurrence of perfluorinated compounds (PFCs) in human blood is known to be widespread; nevertheless, the sources of exposure to humans, including infants, are not well understood. In this study, breast milk collected from seven countries in Asia was analyzed (n = 184) for nine PFCs, including perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA). In addition, five brands of infant formula (n = 21) and 11 brands of dairy milk (n = 12) collected from retail stores in the United States were analyzed, for comparison with PFC concentrations previously reported for breast milk from the U.S. PFOS was the predominant PFC detected in almost all Asian breast milk samples, followed by perfluorohexanesulfonate (PFHxS) and PFOA. Median concentrations of PFOS in breast milk from Asian countries varied significantly; the lowest concentration of 39.4 pg/mL was found in India, and the highest concentration of 196 pg/mL was found in Japan. The measured concentrations were similar to or less than the concentrations previously reported from Sweden, the United States, and Germany (median, 106−166 pg/mL). PFHxS was found in more than 70% of the samples analyzed from Japan, Malaysia, Philippines, and Vietnam, at mean concentrations ranging from 6.45 (Malaysia) to 15.8 (Philippines) pg/mL. PFOA was found frequently only in samples from Japan; the mean concentration for that country was 77.7 pg/mL. None of the PFCs were detected in the infant-formula or dairy-milk samples from the U.S. except a few samples that contained concentrations close to the limit of detection. The estimated average daily intake of PFOS by infants from seven Asian countries, via breastfeeding, was 11.8 ± 10.6 ng/kg bw/day; this value is 7−12 times higher than the estimated adult dietary intakes previously reported from Germany, Canada, and Spain. The average daily intake of PFOA by Japanese infants was 9.6 ± 4.9 ng/kg bw/day, a value 3−10 times greater than the estimated adult dietary intakes reported from Germany and Canada. The highest estimated daily intakes of PFOS and PFOA by infants from seven Asian countries studied were 1−2 orders of magnitude below the tolerable daily intake values recommended by the U.K. Food Standards Agency.Keywords
This publication has 36 references indexed in Scilit:
- Polyfluoroalkyl Chemicals in the U.S. Population: Data from the National Health and Nutrition Examination Survey (NHANES) 2003–2004 and Comparisons with NHANES 1999–2000Environmental Health Perspectives, 2007
- Determinants of Fetal Exposure to Polyfluoroalkyl Compounds in Baltimore, MarylandEnvironmental Science & Technology, 2007
- Levels of 12 Perfluorinated Chemicals in Pooled Australian Serum, Collected 2002−2003, in Relation to Age, Gender, and RegionEnvironmental Science & Technology, 2006
- Perfluorochemicals in Pooled Serum Samples from United States Residents in 2001 and 2002Environmental Science & Technology, 2006
- Perfluorooctanesulfonate and Related Fluorochemicals in Human Blood Samples from ChinaEnvironmental Science & Technology, 2005
- Historical Comparison of Perfluorooctanesulfonate, Perfluorooctanoate, and Other Fluorochemicals in Human BloodEnvironmental Health Perspectives, 2005
- Perfluorooctanesulfonate and Related Fluorochemicals in Human Blood from Several CountriesEnvironmental Science & Technology, 2004
- The Influence of Time, Sex and Geographic Factors on Levels of Perfluorooctane Sulfonate and Perfluorooctanoate in Human Serum over the Last 25 yearsJournal of Occupational Health, 2004
- Quantitative Evaluation of Perfluorooctanesulfonate (PFOS) and Other Fluorochemicals in the Serum of ChildrenJournal of Children's Health, 2004
- Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors.Environmental Health Perspectives, 2003