Isolation, Structure Elucidation, and Antimycobacterial Properties of Dimeric Naphtho‐γ‐pyrones from the Marine‐Derived Fungus Aspergillus carbonarius
- 18 January 2008
- journal article
- research article
- Published by Wiley in Chemistry & Biodiversity
- Vol. 5 (1), 93-100
- https://doi.org/10.1002/cbdv.200890017
Abstract
Two new dimeric naphtho-γ-pyrones, compounds 1 and 2, were isolated from the AcOEt extract of the fungal strain WZ-4-11 of Aspergillus carbonarius, together with eight known analogues, including 10,10′-bifonsecin B (3), 6′-O-demethylnigerone (4), nigerone (5), isonigerone (6), fonsecin (7), rubrofusarin B (8), TMC 256A1 (9), and flavasperone (10). Their structures were elucidated by means of UV, CD, IR, and 1D- and 2D-NMR spectroscopy, in combination with HR-MS analysis. The fully assigned 1H- and 13C-NMR data of 3, and the 13C-NMR data of 6 are reported for the first time. Compounds 1 and 2 showed weak antimycobacterial activities against Mycobacterium tuberculosis H37Rv, with MIC values of 43.0 and 21.5 μM, resp.This publication has 10 references indexed in Scilit:
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