Synthesis, Characterization and Anticancer Activity of Transition Metal Substituted Polyoxometalate-β-Cyclodextrin Composites

Abstract

A novel hybrid composite, namely {[VIV+PMo11O40]⊂[β-CD]} which shows the high percent of apoptosis of MTT assay of A549 cell line (lung cancer) in different concentrations. The composite has been characterized using techniques such as FT-IR, EPR, SEM, EDS and X-ray diffraction. The anticancer (lung cancer A549 cell line) was investigated using direct microscopic observations for drug treated cell line and IC50 value of 1.93. The apoptosis of 45.37 % cell death in cell line of minimum concentration (3.12 μg/mL) shows the good viability of β-CD-POM against lung cancer A549 cell line.