Pro- and anti-fibrotic effects of TGF- in scleroderma
Open Access
- 10 September 2008
- journal article
- review article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 47 (Supplement), v5-v7
- https://doi.org/10.1093/rheumatology/ken275
Abstract
The University of California at Davis 200 and 206 (UCD-200/206) lines of chickens have proven to be the animal model that best reflects the situation in human SSc. We have demonstrated a misbalance of pro-fibrotic (TGF-β1) and anti-fibrotic (TGF-β2 and -β3) TGF-β isoforms as a possible cause for fibrotic alterations in this model. This opens new avenues for diagnosis and therapy for this still intractable condition.This publication has 10 references indexed in Scilit:
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