Head and Neck Cancer
- 1 November 2004
- journal article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 64 (21), 8126-8129
- https://doi.org/10.1158/0008-5472.can-04-2445
Abstract
Head and neck squamous cell carcinoma (HNSCC) is the most common malignant neoplasm arising in the mucosa of the upper aerodigestive tract. Nearly two thirds of patients present with advanced (stage III and IV) disease. Fifty percent of HNSCC patients die of their disease, and 5% of HNSCC patients per year will develop additional second primary tumors. Currently used therapeutic modalities (surgery, radiation, and/or chemotherapy) have been associated with rather modest improvements in patient survival. The Head and Neck Cancer: Research and Therapeutic Opportunities Workshop (held in Washington, DC, May 24–26, 2004) was organized by the Division of Cancer Biology at the National Cancer Institute to identify research areas and directions that will advance understanding of HNSCC biology and accelerate clinical translation. The primary goal of the workshop was to identify the barriers that impede basic science discovery and the translation of these developments to the clinical setting. Over a 2.5-day period, experts in both HNSCC and other cancer-related fields met to identify and prioritize the key areas for future research. The overall consensus was that HNSCC is a relatively understudied malignancy and that investigations that focus on the biology of this tumor have the potential to impact significantly on the prevention and treatment of epithelial malignancies. The chief objective is to communicate these research goals to the cancer biology community and encourage more interest in HNSCC as a tumor model to test translational research hypotheses.Keywords
This publication has 16 references indexed in Scilit:
- Tyrosine kinase inhibitors: Why does the current process of clinical development not apply to them?Cancer Cell, 2004
- The Human MitoChip: A High-Throughput Sequencing Microarray for Mitochondrial Mutation DetectionGenome Research, 2004
- Integrin-mediated targeting of drug delivery to irradiated tumor blood vesselsCancer Cell, 2003
- A molecular signature of metastasis in primary solid tumorsNature Genetics, 2002
- The usefulness of fluorine 18–labelled deoxyglucose positron emission tomography in the investigation of patients with cervical lymphadenopathy from an unknown primary tumorHead & Neck, 2002
- Radiation-induced tumour necrosis factor-α expression: clinical application of transcriptional and physical targeting of gene therapyThe Lancet Oncology, 2002
- Expression of Bcl‐2 Family Proteins in Advanced Laryngeal Squamous Cell Carcinoma: Correlation With Response to Chemotherapy and Organ PreservationThe Laryngoscope, 2002
- Biochemoprevention for Dysplastic Lesions of the Upper Aerodigestive TractJAMA Otolaryngology–Head & Neck Surgery, 1999
- Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and AktMolecular and Cellular Biology, 1997
- Laminin 5 Deposition Promotes Keratinocyte MotilityExperimental Cell Research, 1996