Development of HIV Entry Inhibitors Targeted to the Coiled-Coil Regions of gp41
- 1 March 2000
- journal article
- review article
- Published by Elsevier BV in Biochemical and Biophysical Research Communications
- Vol. 269 (3), 641-646
- https://doi.org/10.1006/bbrc.1999.1972
Abstract
The discoveries that synthetic peptides corresponding to the N- and C-terminal heptad repeat (HR) regions of gp41 have potent anti-HIV activity opened a new avenue to identification of small molecule HIV entry inhibitors targeted to the HIV gp41 coiled-coil regions. Based on the structural information of the HIV gp41 core, three distinct approaches to develop small molecule anti-HIV agents have been reported. Each of these approaches has specific advantages, which will have complementary effects on the design of new strategies for identification of more potent HIV entry inhibitors. It is expected that novel antiviral drugs targeted to the HIV gp41 coiled-coil regions will be developed in the near future for the chemotherapy and/or prophylaxis of HIV infection and AIDS.Keywords
This publication has 30 references indexed in Scilit:
- The AIDS Epidemic — Considerations for the 21st CenturyNew England Journal of Medicine, 1999
- Crystal structure of GCN4-pIQI, a trimeric coiled coil with buried polar residuesJournal of Molecular Biology, 1998
- Antiviral effect of double and triple drug combinations amongst HIV-infected adultsAIDS, 1998
- Atomic structure of the ectodomain from HIV-1 gp41Nature, 1997
- Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesisCell Chemical Biology, 1996
- Identification of d -Peptide Ligands Through Mirror-Image Phage DisplayScience, 1996
- Multifaceted Consequences of Anti-gp41 Monoclonal Antibody 2F5 Binding to HIV Type 1 VirionsAIDS Research and Human Retroviruses, 1995
- Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection.Proceedings of the National Academy of Sciences of the United States of America, 1994
- HIV-1 inhibition by a peptideNature, 1993
- A General Model for the Transmembrane Proteins of HIV and Other RetrovirusesAIDS Research and Human Retroviruses, 1989