Diabetes is a risk factor for the progression and prognosis of COVID‐19
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Open Access
- 31 March 2020
- journal article
- research article
- Published by Wiley in Diabetes/Metabolism Research and Reviews
- Vol. 36 (7), e3319
- https://doi.org/10.1002/dmrr.3319
Abstract
Aim To figure out whether diabetes is a risk factor influencing the progression and prognosis of 2019 novel coronavirus disease (COVID‐19). Materials and Methods A total of 174 consecutive patients confirmed with COVID‐19 were studied. Demographic data, medical history, symptoms and signs, laboratory findings, chest computed tomography (CT) as well we treatment measures were collected and analyzed. Results We found that COVID‐19 patients without other comorbidities but with diabetes (n=24) were at higher risk of severe pneumonia, release of tissue injury‐related enzymes, excessive uncontrolled inflammation responses and hypercoagulable state associated with dysregulation of glucose metabolism. Furthermore, serum levels of inflammation related biomarkers such as IL‐6, C‐reactive protein, serum ferritine and coagulation index, D‐dimer, were significantly higher (p< 0.01) in diabetic patients compared with those without, suggesting that patients with diabetes are more susceptible to an inflammatory storm eventually leading to rapid deterioration of COVID‐19. Conclusions Our data support the notion that diabetes should be considered as a risk factor for a rapid progression and bad prognosis of COVID‐19. More intensive attention should be paid to patients with diabetes, in case of rapid deterioration.Keywords
Funding Information
- National Natural Science Foundation of China (31770983, 81601747, 81974249)
This publication has 23 references indexed in Scilit:
- Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infectionsImmunology, 2015
- The immune system's involvement in obesity-driven type 2 diabetesSeminars in Immunology, 2012
- Diabetes and Infection: Is There a Link? - A Mini-ReviewGerontology, 2012
- Binding of SARS coronavirus to its receptor damages islets and causes acute diabetesActa Diabetologica, 2009
- Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARSDiabetic Medicine, 2006
- Increased Risk of Common Infections in Patients with Type 1 and Type 2 Diabetes MellitusClinical Infectious Diseases, 2005
- A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injuryNature Medicine, 2005
- Viruses and DiabetesAnnals of the New York Academy of Sciences, 2002
- A Human Homolog of Angiotensin-converting EnzymeJournal of Biological Chemistry, 2000
- Infections in Patients with Diabetes MellitusThe New England Journal of Medicine, 1999