Component-resolved diagnostics in food allergy
- 1 June 2006
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Allergy and Clinical Immunology
- Vol. 6 (3), 234-240
- https://doi.org/10.1097/01.all.0000225166.90768.d6
Abstract
The purpose of this paper is to review and discuss recent studies on component-resolved diagnostics in food allergy, involving panels of pure allergen molecules or arrays of peptides derived from allergen sequences, and to summarize the reporting of new food allergens during the past 2 years. Several component-resolved diagnostic studies in food allergy suggest that the use of panels of allergen molecules may allow refined clinical information to be obtained on the likelihood or severity of an allergic food reaction and regarding diagnostic specificity. Further, in some studies the use of pure allergen molecules has led to a clearly higher sensitivity of the immunoglobulin E immunoassay compared with conventional allergen extracts. While common diagnostic methods in allergy assess the presence or absence of allergen-specific sensitization, to date, no in-vitro or in-vivo test exists which exhibits full correlation with clinical food allergy. A multitude of recently reported findings and observations indicate that molecular analysis of allergen sensitization pattern may serve to enhance the clinical utility of immunoglobulin E antibody-based allergy diagnostics. Pure natural and recombinant allergen molecules as well as panels of synthetic peptides have been used for this purpose.Keywords
This publication has 73 references indexed in Scilit:
- Importance of Databases in Experimental and Clinical AllergologyInternational Archives of Allergy and Immunology, 2005
- Prevalence of food allergy and its relationship to asthma and allergic rhinitis in schoolchildrenAllergy, 2005
- Food allergy – accurately identifying clinical reactivityAllergy, 2005
- The SAFE project: ‘plant food allergies: field to table strategies for reducing their incidence in Europe’ an EC‐funded studyAllergy, 2005
- Strong allergenicity of Pru av 3, the lipid transfer protein from cherry, is related to high stability against thermal processing and digestionJournal of Allergy and Clinical Immunology, 2004
- Monitoring of IgE-mediated food allergy in childhoodActa Paediatrica, 2004
- Update on food allergyJournal of Allergy and Clinical Immunology, 2004
- Component-resolved diagnosis with recombinant allergens in patients with cherry allergyJournal of Allergy and Clinical Immunology, 2002
- Lipid Transfer Protein: A Pan-Allergen in Plant-Derived Foods That Is Highly Resistant to Pepsin DigestionInternational Archives of Allergy and Immunology, 2000
- Food hypersensitivity and atopic dermatitis: Pathophysiology, epidemiology, diagnosis, and managementJournal of Allergy and Clinical Immunology, 1999