Acute phase proteins in cattle: discrimination between acute and chronic inflammation
- 17 April 1999
- journal article
- research article
- Published by Wiley in Veterinary Record
- Vol. 144 (16), 437-441
- https://doi.org/10.1136/vr.144.16.437
Abstract
Acute phase proteins such as serum amyloid A, haptoglobin, and α1 -acid glycoprotein have been identified as markers of inflammation in cattle because they are produced by the liver in response to pro-inflammatory cytokines. This study was designed to assess whether they could be used to discriminate between acute and chronic inflammation. Their concentrations were measured in serum samples from 81 cattle in which inflammation was classified by thorough clinical examination, supported by postmortem findings, as being acute in severity in 31 and chronic in 50. The classical haematological markers of inflammation were also determined in blood from the animals. Serum amyloid A had a maximum (100 per cent) clinical sensitivity in discriminating between the acute and chronic cases, and haptoglobin had the highest clinical specificity of 76 per cent; counts of neutrophils and band neutrophils had sensitivities of 71 per cent and 42 per cent and specificities of 30 per cent and 72 per cent, respectively. It was concluded that serum amyloid A and haptoglobin may be used to discriminate between acute and chronic inflammatory conditions.Keywords
This publication has 26 references indexed in Scilit:
- Primary bovine hepatocytes in the study of cytokine induced acute-phase protein secretion in vitroVeterinary Immunology and Immunopathology, 1996
- Acute phase response in heifers with experimentally induced mastitisJournal of Dairy Research, 1996
- Quantitative determination of bovine serum haptoglobin in experimentally induced Escherichia coli mastitisResearch in Veterinary Science, 1996
- Influence of physical stress on the plasma concentration of serum amyloid‐a (SAA) and haptoglobin (HP) in calvesVeterinary Quarterly, 1995
- Immediate responses in serum tnfα and acute phase protein concentrations to infection with Pasteurella haemolytica A1 in calvesResearch in Veterinary Science, 1994
- Haptoglobin as an indicator of infection in sheepPublished by Wiley ,1994
- Bovine haptoglobin response in clinically defined field conditionsPublished by Wiley ,1991
- Stimulation of Hepatic Acute Phase Response by Cytokines and GlucocorticoidsaAnnals of the New York Academy of Sciences, 1989
- Isolation, characterization, and quantitative measurement of serum .ALPHA.1-acid glycoprotein in cattle.The Japanese Journal of Veterinary Science, 1989
- Quantitative determination of bovine serum haptoglobin and its elevation in some inflammatory diseases.The Japanese Journal of Veterinary Science, 1982