Pars Plana Vitrectomy with Internal Limiting Membrane Peeling for Treatment-Naive Diabetic Macular Edema: A Prospective, Uncontrolled Pilot Study
Open Access
- 1 January 2021
- journal article
- research article
- Published by Taylor & Francis Ltd in Clinical Ophthalmology
- Vol. 15, 2619-2624
- https://doi.org/10.2147/OPTH.S320214
Abstract
Purpose: To report the outcomes in subjects undergoing pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling for the management of treatment-naive diabetic macular edema (DME). Methods: Ten treatment-naive subjects with non-proliferative diabetic retinopathy prospectively underwent PPV with ILM peeling for the treatment of DME at a single university-affiliated institution. The preoperative features, intraoperative details and postoperative outcomes were collected and analyzed. Results: All 10 subjects underwent PPV with ILM peeling without significant intraoperative or postoperative complications at 6 months follow-up. Visual acuity improved from a baseline of 0.74 (95% CI: 0.48-1.0) logMAR (Snellen 20/110) to 0.46 (95% CI: 0.30.62) logMAR (Snellen 20/58) at 6 months follow-up (p=0.045). Optical coherence tomography central macular thickness reduced from a baseline of 456 (95% CI: 394.7-516.4) microns to 316.8 (95% CI: 275.9-357.7) microns at 6 months follow-up (p < 0.001). Conclusion: This pilot study suggests that PPV with ILM peeling may be a viable treatment option for the management of treatment naive DME in subjects with non-proliferative diabetic retinopathy. Development of a randomized controlled trial may be justified to validate the results of this study.This publication has 18 references indexed in Scilit:
- Vitrectomy for diabetic macular edema: a systematic review and meta-analysisCanadian Journal of Ophthalmology, 2014
- Ranibizumab for Diabetic Macular EdemaOphthalmology, 2012
- Randomized, Sham-Controlled Trial of Dexamethasone Intravitreal Implant in Patients with Macular Edema Due to Retinal Vein OcclusionOphthalmology, 2010
- Vitrectomy Outcomes in Eyes with Diabetic Macular Edema and Vitreomacular TractionOphthalmology, 2010
- LONG-TERM FOLLOW-UP OF VITRECTOMY FOR DIFFUSE NONTRACTIONAL DIABETIC MACULAR EDEMARetina, 2009
- Vitrectomy for diabetic macular oedemaEye, 2008
- Intravitreal Triamcinolone plus Sequential Grid Laser versus Triamcinolone or Laser Alone for Treating Diabetic Macular Edema: Six-Month OutcomesOphthalmology, 2007
- Vitrectomy for Diabetic Macular Traction and Edema Associated with Posterior Hyaloidal TractionOphthalmology, 1992
- The Role of the Vitreous in Diabetic Macular EdemaOphthalmology, 1988
- Photocoagulation for Diabetic Macular EdemaAmerican Journal of Ophthalmology, 1985