The Short-Lasting Analgesia and Long-Term Antihyperalgesic Effect of Intrathecal Clonidine in Patients Undergoing Colonic Surgery
- 1 August 2005
- journal article
- clinical trial
- Published by Ovid Technologies (Wolters Kluwer Health) in Anesthesia & Analgesia
- Vol. 101 (2), 566-572
- https://doi.org/10.1213/01.ane.0000157121.71808.04
Abstract
In this study, we investigated the antihyperalgesic effect of clonidine after surgery. Sixty patients undergoing right colic resection were studied. Patients were randomized to receive prior to general anesthesia a 2-mL intrathecal (IT) injection of 300 μg of clonidine or saline, or 10 mg of bupivacaine. General anesthesia was achieved using a target concentration propofol infusion and monitored using bispectral index. Postoperative analgesia was provided by morphine IV given through a patient-controlled analgesia device. Postoperative analgesia was assessed by morphine requirements and visual analog scale pain scores at rest, cough, and movement during the first 72 h. Mechanical hyperalgesia was measured by von Frey filaments. Patients were questioned regarding residual pain at 2 wk,1, 6, and 12 mo. The patient-controlled analgesia morphine requirements were significantly smaller in the IT clonidine group (31.5 ± 12 versus 91 ± 25.5 and 43 ± 15 mg, respectively, in groups clonidine, saline, and bupivacaine: PThis publication has 19 references indexed in Scilit:
- Electrophysiological characterisations of rat lamina I dorsal horn neurones and the involvement of excitatory amino acid receptorsPain, 2004
- Acute Opioid ToleranceAnesthesiology, 2000
- The Mechanical Antihyperalgesic Effect of Intrathecally Administered MPV-2426, a Novel α2-Adrenoceptor Agonist, in a Rat Model of Postoperative PainAnesthesiology, 2000
- Norepinephrine Facilitates Inhibitory Transmission in Substantia Gelatinosa of Adult Rat Spinal Cord (Part 1)Anesthesiology, 2000
- Norepinephrine Facilitates Inhibitory Transmission in Substantia Gelatinosa of Adult Rat Spinal Cord (Part 2)Anesthesiology, 2000
- Epidural Clonidine or Bupivacaine as the Sole Analgesic Agent during and after Abdominal SurgeryAnesthesiology, 1999
- Intrathecal, but Not Intravenous, Clonidine Reduces Experimental Thermal or Capsaicin-Induced Pain and Hyperalgesia in Normal VolunteersAnesthesia & Analgesia, 1998
- Epidural Clonidine Used as the Sole Analgesic Agent during and after Abdominal SurgeryAnesthesiology, 1997
- α2-Adrenergic Agonists for Regional AnesthesiaAnesthesiology, 1996
- Intravenous or Epidural Clonidine for Intra- and Postoperative AnalgesiaAnesthesiology, 1993