Exploring a New Twist on Tumor Metastasis
Open Access
- 1 May 2006
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 66 (9), 4549-4552
- https://doi.org/10.1158/0008-5472.can-05-3850
Abstract
Unraveling the genetic programs that drive -metastasis may offer insights into how to limit or prevent this deadly aspect of cancer progression. Our recent studies indicate that tumor cell metastasis involves the activity of the transcription factor, Twist, which regulates epithelial-mesenchymal transition and early embryonic morphogenesis. Here, we review the Twist signaling pathway during normal development and discuss how the transcription factor Twist and the epithelial-mesenchymal transition program impinge their biological functions during tumor metastasis. (Cancer Res 2006; 66(9): 4549-52)This publication has 21 references indexed in Scilit:
- Expression of the Transcription Factors Snail, Slug, and Twist and Their Clinical Significance in Human Breast CancerAnnals of Surgical Oncology, 2005
- Oncogenic cooperation between H-Twist and N-Myc overrides failsafe programs in cancer cellsCancer Cell, 2004
- Expression Profiling Reveals Novel Pathways in the Transformation of Melanocytes to MelanomasCancer Research, 2004
- Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor MetastasisCell, 2004
- Correlation of Snail expression with histological grade and lymph node status in breast carcinomasOncogene, 2002
- New functions for the matrix metalloproteinases in cancer progressionNature Reviews Cancer, 2002
- Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasisThe Journal of cell biology, 2002
- The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expressionNature, 2000
- The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cellsNature, 2000
- twist is a potential oncogene that inhibits apoptosisJournal of Bone and Joint Surgery, 1999