Differences in Genotypes ofHelicobacter pylorifrom Different Human Populations
- 1 June 2000
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 182 (11), 3210-3218
- https://doi.org/10.1128/jb.182.11.3210-3218.2000
Abstract
DNA motifs at several informative loci in more than 500 strains ofHelicobacter pylori from five continents were studied by PCR and sequencing to gain insights into the evolution of this gastric pathogen. Five types of deletion, insertion, and substitution motifs were found at the right end of the H. pylori cagpathogenicity island. Of the three most common motifs, type I predominated in Spaniards, native Peruvians, and Guatemalan Ladinos (mixed Amerindian-European ancestry) and also in native Africans and U.S. residents; type II predominated among Japanese and Chinese; and type III predominated in Indians from Calcutta. Sequences in the cagA gene and in vacAm1 type alleles of the vacuolating cytotoxin gene (vacA) of strains from native Peruvians were also more like those from Spaniards than those from Asians. These indications of relatedness of Latin American and Spanish strains, despite the closer genetic relatedness of Amerindian and Asian people themselves, lead us to suggest that H. pylori may have been brought to the New World by European conquerors and colonists about 500 years ago. This thinking, in turn, suggests that H. pylori infection might have become widespread in people quite recently in human evolution.Keywords
This publication has 68 references indexed in Scilit:
- Hypothesis: The Changing Relationships ofHelicobacter pyloriand Humans: Implications for Health and DiseaseThe Journal of Infectious Diseases, 1999
- Full‐Length Sequence Analysis of thevacAGene from Cytotoxic and NoncytotoxicHelicobacter pyloriThe Journal of Infectious Diseases, 1998
- Helicobacter pyloriPopulations in Peruvian PatientsClinical Infectious Diseases, 1997
- Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolutionMolecular Microbiology, 1997
- Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii Science, 1996
- Analysis of Genetic Diversity in Cytotoxin-Producing and Non-Cytotoxin Producing Helicobacter pylori StrainsThe Journal of Infectious Diseases, 1995
- Helicobacter pylori: comparison of DNA fingerprints provides evidence for intrafamilial infection.Gut, 1993
- How clonal are bacteria?Proceedings of the National Academy of Sciences, 1993
- The Role of Epidemic Infectious Diseases in the Discovery of AmericaAllergy and Asthma Proceedings, 1992
- Naturally occurring chronic gastritis and C pylori infection in the rhesus monkey: a potential model for gastritis in man.Gut, 1988