Autophagy: Friend or Foe in Breast Cancer Development, Progression, and Treatment
Open Access
- 1 January 2011
- journal article
- Published by Hindawi Limited in International Journal of Breast Cancer
- Vol. 2011, 1-7
- https://doi.org/10.4061/2011/595092
Abstract
Autophagy is a catabolic process responsible for the degradation and recycling of long-lived proteins and organelles by lysosomes. This degradative pathway sustains cell survival during nutrient deprivation, but in some circumstances, autophagy leads to cell death. Thereby, autophagy can serve as tumor suppressor, as the reduction in autophagic capacity causes malignant transformation and spontaneous tumors. On the other hand, this process also functions as a protective cell-survival mechanism against environmental stress causing resistance to antineoplastic therapies. Although autophagy inhibition, combined with anticancer agents, could be therapeutically beneficial in some cases, autophagy induction by itself could lead to cell death in some apoptosis-resistant cancers, indicating that autophagy induction may also be used as a therapy. This paper summarizes the most important findings described in the literature about autophagy and also discusses the importance of this process in clinical settings.Keywords
This publication has 81 references indexed in Scilit:
- Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxelBMC Cancer, 2011
- Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 SignalingPLOS ONE, 2009
- Abl Kinases Regulate Autophagy by Promoting the Trafficking and Function of Lysosomal ComponentsOnline Journal of Public Health Informatics, 2008
- Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl–mediated drug resistanceBlood, 2007
- Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphomaJCI Insight, 2007
- Control of Macroautophagy by Calcium, Calmodulin-Dependent Kinase Kinase-β, and Bcl-2Molecular Cell, 2007
- Endoplasmic Reticulum Stress Triggers AutophagyOnline Journal of Public Health Informatics, 2006
- The role of autophagy in cancer development and response to therapyNature Reviews Cancer, 2005
- LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingThe EMBO Journal, 2000
- A New Anti-oestrogenic Agent in Late Breast Cancer: An Early Clinical Appraisal of ICI46474British Journal of Cancer, 1971