Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?
Top Cited Papers
- 1 November 2010
- journal article
- perspective
- Published by Elsevier BV in Cell
- Vol. 143 (5), 686-693
- https://doi.org/10.1016/j.cell.2010.11.016
Abstract
No abstract availableThis publication has 52 references indexed in Scilit:
- Enhancement of proteasome activity by a small-molecule inhibitor of USP14Nature, 2010
- Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligaseNature Biotechnology, 2010
- Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate ImmunityCell, 2010
- Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokinesNature Immunology, 2009
- Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3The EMBO Journal, 2009
- Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 ConjugationMolecular Cell, 2008
- Function and regulation of protein neddylationEMBO Reports, 2008
- Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of ConjugationCell, 2008
- Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting ComplexCell, 2008
- Smac Mimetics and TNFα: A Dangerous Liaison?Cell, 2007