Candida Meningitis Successfully Treated with Amphotericin B

Abstract

THE following is the twenty-second case of candidiasis of the central nervous system reported since 1933^{1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21} and the second to have been treated successfully with amphotericin B.Case ReportA 1-month-old male infant weighing 2.9 kg. (6 pounds, 7 ounces) was admitted to the hospital on November 30, 1960, with candida enteritis of 3 weeks' duration.²² This condition subsided within 3 days of oral administration of nystatin, 100,000 units every 8 hours. Isolation of a coagulase-positive Staphylococcus aureus from the blood necessitated intravenous infusion of chloramphenicol, 150 mg. per day, and penicillin, 2,000,000 units daily, for 7 days.A subsequent . . .