Synthesis and characterization of the core–shell magnetic molecularly imprinted polymers (Fe3O4@MIPs) adsorbents for effective extraction and determination of sulfonamides in the poultry feed
- 1 July 2012
- journal article
- research article
- Published by Elsevier BV in Journal of Chromatography A
- Vol. 1245, 8-16
- https://doi.org/10.1016/j.chroma.2012.04.061
Abstract
In this study, we present a general method to prepare the core-shell magnetic molecularly imprinted polymers (MIPs) nanoparticles (NPs) for sulfamethazine (SMZ). The resulting Fe₃O₄@MIPs NPs possess a highly improved imprinting effect, fast adsorption kinetics and high adsorption capacity, and can be applied to extract sulfonamide in the poultry feed. In this protocol, the magnetite NPs were synthesized by co-precipitating Fe²⁺ and Fe³⁺ in an ammonia solution first. Silica was then coated on the Fe₃O₄ NPs using a sol-gel method to obtain silica shell magnetic NPs. Subsequently, the vinyl groups were grated onto silica-modified Fe₃O₄ surface by 3-methacryloyloxypropyltrimethoxysilane. Finally, the MIPs films were formed on the surface of Fe₃O₄@SiO₂ by the copolymerization of vinyl end groups with functional monomer, methacrylic acid, cross-linking agent, ethylene glycol dimethacrylate, the initiator azo-bis-isobutyronitrile and template molecule, sulfamethazine. The morphology, magnetic, adsorption and recognition properties of Fe₃O₄@MIPs NPs were characterized using transmission electron microscope (TEM), scanning electron microscope (SEM), Fourier transform infrared (FT-IR) spectrometer, vibrating sample magnetometer (VSM) and re-binding experiments. The results showed that the binding sites of Fe₃O₄@MIPs were good accessibility, fast adsorption rate and the maximum adsorption capacity of Fe₃O₄@MIPs to SMZ was 344.8 μg g⁻¹. The selectivity of the obtained Fe₃O₄@MIPs NPs were elucidated by the different rebinding capability of SMZ and structural related sulfonamides in the mixed solution. The results indicated that the Fe₃O₄@MIPs had high imprinting factor 9.5 and significant selectivity. A method was developed for enrichment and determination of SMZ in the poultry feed samples with recoveries of duck and chicken feed ranging from 63.3 to 76.5% and 68.7 to 74.7%, respectively and the relative standard deviations (RSD) (<6.7%).Keywords
This publication has 53 references indexed in Scilit:
- Preparation and characterisation of core–shell CNTs@MIPs nanocomposites and selective removal of estrone from water samplesTalanta, 2011
- Development of sulfamethoxazole-imprinted polymers for the selective extraction from watersJournal of Hazardous Materials, 2009
- Solid phase extraction of food contaminants using molecular imprinted polymersAnalytica Chimica Acta, 2007
- Monolithic molecularly imprinted polymer for sulfamethoxazole and molecular recognition properties in aqueous mobile phaseAnalytica Chimica Acta, 2006
- Simultaneous determination of 17 sulfonamide residues in porcine meat, kidney and liver by solid-phase extraction and liquid chromatography–tandem mass spectrometryAnalytica Chimica Acta, 2005
- Solid-phase molecularly imprinted on-line preconcentration and voltammetric determination of sulfamethazine in milkAnalytica Chimica Acta, 2005
- Magnetic properties of γ‐Fe2O3 nanoparticles made by coprecipitation methodPhysica Status Solidi (b), 2004
- Approaches to the rational design of molecularly imprinted polymersAnalytica Chimica Acta, 2003
- Rapid high-performance liquid chromatographic determining technique of sulfamonomethoxine, sulfadimethoxine, and sulfaquinoxaline in eggs without use of organic solventsAnalytica Chimica Acta, 2003
- Quercetin–La(III) complex for the fluorimetric determination of nucleic acidsAnalytica Chimica Acta, 1999