Migraine and obesity: epidemiology, possible mechanisms and the potential role of weight loss treatment
Open Access
- 27 April 2011
- journal article
- review article
- Published by Wiley in Obesity Reviews
- Vol. 12 (5), e362-e371
- https://doi.org/10.1111/j.1467-789x.2010.00791.x
Abstract
Migraine and obesity are two public health problems of enormous scope that are responsible for significant quality of life impairment and financial cost. Recent research suggests that these disorders may be directly related with obesity exacerbating migraine in the form of greater headache frequency and severity, or possibly increasing the risk for having migraine. The relationship between migraine and obesity may be explained through a variety of physiological, psychological and behavioural mechanisms, many of which are affected by weight loss. Given that weight loss might be a viable approach for alleviating migraine in obese individuals, randomized controlled trials are needed to test the effect of weight loss interventions in obese migraineurs. Large‐scale weight loss trials have shown that behavioural interventions, in particular, can produce sustained weight losses and related cardiovascular improvements in patients who are diverse in body weight, age and ethnicity. Consequently, these interventions may provide a useful treatment model for showing whether weight loss reduces headache frequency and severity in obese migraineurs, and offering further insight into pathways through which weight loss might exert an effect.Keywords
This publication has 111 references indexed in Scilit:
- Thermal Nociception is Decreased by Hypocretin-1 and an Adenosine A1 Receptor Agonist Microinjected into the Pontine Reticular Formation of Sprague Dawley RatThe Journal of Pain, 2010
- Associations between sleep disturbance and primary headaches: the third Nord-Trøndelag Health StudyThe Journal of Headache and Pain, 2010
- Objective quantification of physical activity in bariatric surgery candidates and normal-weight controlsSurgery for Obesity and Related Diseases, 2010
- A Randomized Study on the Effect of Weight Loss on Obstructive Sleep Apnea Among Obese Patients With Type 2 DiabetesThe Sleep AHEAD StudyEffect of Weight Loss on Obstructive Sleep ApneaJAMA Internal Medicine, 2009
- Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulationProceedings of the National Academy of Sciences of the United States of America, 2009
- One‐year Weight Losses in the Look AHEAD Study: Factors Associated With SuccessObesity, 2009
- Impact of a Weight Management Program on Health-Related Quality of Life in Overweight Adults With Type 2 DiabetesJAMA Internal Medicine, 2009
- Epidemiology and comorbidity of headacheThe Lancet Neurology, 2008
- BMI and Headache Among Women: Results From 11 Epidemiologic DatasetsObesity, 2008
- Association Between Obesity and Psychiatric Disorders in the US Adult PopulationArchives of General Psychiatry, 2006